Skewing in individual TCR BV families as determined by the 3-criteria analysis.

In this scattergram, the frequency of skewing in individual TCR BV family in the control group (black circles: healthy individuals, white circles: transfused, sickle cell disease or thalassemia patients) and the PNH patient group (gray circles) is shown. The mean frequency of skewing in the control and patient groups are 11.4% and 28%, respectively, P = .002.