Molecular organization of DOK1.

(A) Schematic representation of the DOK1 gene. Exons and introns are depicted as hatched bars and filled bars, respectively. The numbers show exon/intron boundaries relative to the position of theDOK1 start codon at position 1. Open boxes show signal peptides, ● indicates putative N-linked glycosylation sites, and ○ indicates putative N-myristoylation sites. (B) Predicted amino acid sequence of DOK1.Signal peptide depicts the predicted signal peptide; GPI-anchor motif, the predicted GPI anchor; ART, the ART motif; and *, the amino acid position corresponding to identified SNP sites.