American Society of Hematology

Fig. 5.

$Fig. 5. Reductions in absolute lymphocyte count and lymph node size following an infusion of autologous Ad-CD154–transduced CLL cells. / (A) Complete blood count and manual differential were performed at the indicated time points from the day of infusion of Ad-CD154 CLL cells (day 0). Absolute lymphocyte counts were calculated and then normalized with respect to the lymphocyte count obtained before leukapheresis. (B) Lymph node area was assessed by nodal palpation in 2 dimensions in right and left cervical, supraclavicular, and axillary regions. The largest lymph node in each of the right and left nodal regions palpated on the day of cell infusion was selected and followed over time. The total lymph node bulk was represented as the sum area of the largest lymph node in each of the right and left nodal regions. The normalized lymph node area represents the sum lymph node area at a particular time as a fraction of sum area on day of infusion (day 0) times 100.$

Reductions in absolute lymphocyte count and lymph node size following an infusion of autologous Ad-CD154–transduced CLL cells.

(A) Complete blood count and manual differential were performed at the indicated time points from the day of infusion of Ad-CD154 CLL cells (day 0). Absolute lymphocyte counts were calculated and then normalized with respect to the lymphocyte count obtained before leukapheresis. (B) Lymph node area was assessed by nodal palpation in 2 dimensions in right and left cervical, supraclavicular, and axillary regions. The largest lymph node in each of the right and left nodal regions palpated on the day of cell infusion was selected and followed over time. The total lymph node bulk was represented as the sum area of the largest lymph node in each of the right and left nodal regions. The normalized lymph node area represents the sum lymph node area at a particular time as a fraction of sum area on day of infusion (day 0) times 100.

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