Reversal of antibody-induced thrombocytopenia by lip-clod.

Two groups of 6 BALB/c mice were injected intraperitoneally with 25μL of Ab. After 4 hours of Ab treatment the mice were bled for platelet counting (time = 0 hours) and 15 minutes later the mice were injected intravenously with 200 μL of lip-PBS or lip-clod. At 24 hours the animals were bled for platelet count and reinjected with Ab. Finally, the platelet number was evaluated at 48 hours. Bars represent mean ± SEM. *P < .001 and °P < .01, significantly different from control group (before Ab injection).^#P < .001, significantly different from lip-PBS–treated group, Bonferroni test (2-tailed).