Down-regulation of CXCR4 on CLL B cells cultured with NLC.

Histograms of leukemia B cells from 2 representative patients with CLL, indicating the relative red (anti-CXCR4) fluorescence intensity of CLL cells before (shaded) or after coculture with NLC (bold lines). Thin lines represent the isotype control staining. MFIR values are displayed next to each histogram.