Fig. 1.
Inhibition of factor Xa by ZPI.
ZPI inhibition of factor Xa is shown in the presence and absence of PZ. Mixtures containing factor Xa (5 nmol/L), phospholipids (15 μmol/L), CaCl2 (4 mmol/L), with or without PZ (40 nmol/L), were constructed in HSA at room temperature, and the reaction was initiated by the addition of ZPI (69 nmol/L). Samples were removed at various times and diluted in HSA, and remaining factor Xa activity was determined by coagulation assay. ▿, without PZ or ZPI; ○, ZPI with PZ; and ●, ZPI without PZ.
