Fibronectin synthesis by HCs stimulated with surface-bound HA or anti-CD44.

HCs were cultured in serum-free medium for 24 hours on plastic coated with HA (A) or anti-CD44 (B). Plastic coated with albumin (C) or with IgG2a (D) was used as control. Fibronectin (FN) was detected by indirect staining with an anti-FN MoAb. Representative examples of 5 experiments with cells from 3 HCL patients are shown.