Fig. 2.
Fig. 2. Proliferation of HL-60, NB4, and UF-1 cells. / The effects of the combination of ATRA and HIV-1 protease inhibitors on proliferation of HL-60 (A), NB4 (B), and UF-1 (C) are shown. Cells were cultured with various concentrations of ATRA (10−8-10−6 mol/L for HL-60 and UF-1; 10−11-10−9 mol/L for NB4) either alone or in combination with indinavir (2 × 10−5 mol/L), ritonavir (1 × 10−5 mol/L), or saquinavir (1 × 10−5 mol/L). Data represent mean ± SD of triplicate cultures and results represent at least 3 independent experiments. ■, ATRA; ⋄, ATRA + Indinavir (2 × 10-5 mol/L; ○, ATRA + Ritonavir (1 × 10-5 mol/L); ▵, ATRA + Saquinavir (1 × 10-5 mol/L).

Proliferation of HL-60, NB4, and UF-1 cells.

The effects of the combination of ATRA and HIV-1 protease inhibitors on proliferation of HL-60 (A), NB4 (B), and UF-1 (C) are shown. Cells were cultured with various concentrations of ATRA (10−8-10−6 mol/L for HL-60 and UF-1; 10−11-10−9 mol/L for NB4) either alone or in combination with indinavir (2 × 10−5 mol/L), ritonavir (1 × 10−5 mol/L), or saquinavir (1 × 10−5 mol/L). Data represent mean ± SD of triplicate cultures and results represent at least 3 independent experiments. ■, ATRA; ⋄, ATRA + Indinavir (2 × 10-5 mol/L; ○, ATRA + Ritonavir (1 × 10-5 mol/L); ▵, ATRA + Saquinavir (1 × 10-5 mol/L).

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