CLHb shortened the time to complete arterial occlusion in a rabbit model of carotid thrombosis.

Carotid blood flow was measured in rabbits given an infusion ofo-raffinose CLHb (n = 10) or 5% HSA (n = 10). At time 0 (dotted line), the right carotid artery was clamped briefly and a 500-μA current was applied to the artery until complete and sustained occlusion occurred. (A) Median carotid blood flow in rabbits given an infusion of CLHb (solid circles) or HSA (open circles). The solid bar denotes the period of infusion of the test substance; the hatched bar denotes the application of current. (B) Time to complete carotid occlusion in CLHb- and HSA-treated rabbits. The data shown are means; error bars denote 1 SD. *P < .05 compared with HSA.