CLHb enhanced the aggregation of rabbit platelets stimulated with U46619 and arachidonic acid (AA) but not adenosine diphosphate (ADP)

. Impedance aggregometry was performed on rabbit whole blood stimulated with U46619, ADP, AA, or collagen in the presence or absence of CLHb (50 g/L). Δ aggregation was calculated as the aggregation amplitude in the presence of o-raffinose CLHb minus that observed in Ringer's lactate alone, measured 6 minutes after the addition of the agonist (n = 24 data pairs per treatment arm). The data shown are means; error bars represent 1 SD. Mean absolute impedance values forU46619, ADP, AA, and collagen in the presence of Ringer's lactate alone were 1.34, 1.87, 5.69, and 9.11 Ω, respectively. *P < .001 compared with results with Ringer's lactate alone.