Fig. 2.
Fibrinogen deficiency diminished the metastatic potential of circulating tumor cells but not the growth of metastatic foci.
Representative examples of metastatic pulmonary foci produced 21 days after intravenous injection of 1.7 × 104 B16-BL6 cells (A) and 1 × 105 LLC cells (B) into the lateral tail vein. Lungs from fibrinogen-deficient mice are pictured on the right and controls on the left. (C) Scatter plot of the size distribution of metastatic foci with transplanted B16-BL6 (left) and LLC (right) in fibrinogen-deficient (Fib−) and control (Fib+) mice. See text for definitions of arbitrary units used for size distribution. (P values were generated using the Studentt test.)
