Fig. 3.
Effect of Dex and IL-6 on response of MM cells to Thal and the IMiDs.
(A) MM.1S cells were cultured with 1.0 μM Thal, IMiD1, IMiD2, or IMiD3 in control media alone (■) or with 0.001 (▧), 0.01 (▤), and 0.1 μmol/L (▪) Dex. (B) MM.1S cells were cultured in control media alone and with 0.1 and 1.0 μmol/L Thal, IMiD1, IMiD2, or IMiD3 either in the presence (■) or absence (▪) of IL-6 (50 ng/mL). In each case, 3H-TdR uptake was measured during the last 8 hours of 48-hour cultures. Values represent the mean (± SD) 3H-TdR (cpm) of triplicate cultures.
