Fig. 1.
Cytochalasin D enhances vWf-induced platelet aggregation.
(A) Washed platelets (3 × 108/mL) were incubated with vehicle alone (−CD) or 5 μmol/L CD (+CD), then aggregated with the indicated concentrations of HvWf in the presence of 1 mg/mL ristocetin (i,ii) or BvWf alone (iii,iv). The aggregation tracings are from 1 experiment, representative of 10 independent experiments. (B) PRP was incubated with 5 μmol/L CD for 10 minutes followed by the addition of ristocetin at the indicated concentrations to initiate aggregation under stirred conditions.
