LOH analysis.

(A) Ideogram depicting the chromosome 6p and q arms. All microsatellite markers used for LOH analysis and their location are indicated. On the right-hand side, the LOH data of the extranodal and nodal series of DLCLs are summarized. Each bar represents the percentage of informative cases with LOH (their number depicted at the right). (B) Example of 2 testicular lymphomas (T18 and T25) that show retention of heterozygosity at marker D6S1666 near HLA-DQB1, and allelic imbalance is shown at both flanking markers C47 and X87 344. This suggests a homozygous deletion. Allelic imbalance was determined by comparing the ratio between alleles of tumor DNA (T) and normal DNA (N).