Fig. 2.
Effects of CDDP at the indicated doses in Hep3B cells with or without exposure to hypoxia or Co.
(A) EPO protein production and cell viability at 24 hours. (B) Cell viability at 6 hours. (C) EPO mRNA expression at 6 hours. (D) DNA binding activity of hypoxia inducible factor-1 (HIF-1) at 6 hours. Experimental conditions were as described in the legend to Figure 1.