Fig. 4.
Resting platelets adhere to vWF in histamine-treated mesenteric venules.
Histamine (1 mmol/L) was injected intraperitoneally into recipient mice. Ten minutes later, washed and fluorescently labeled platelets from WT, P−/−, and vWF−/− mice were transfused into recipient mice of the same genotype. Analysis of the platelet–vessel wall interactions started immediately after platelet transfusion. The number of adherent fluorescent platelets/mm2·min, determined in a 4-minute period, was averaged from 4 to 6 venules in each animal. n = 4 to n = 6 animals; *P < .001 vWF−/− vs WT or P−/− mice.
