Fig. 7.
Fig. 7. Reduction of anti-Id Ab response by immunization with Id-CTLA4Y104A mutant protein. / Mice were immunized twice by intraperitoneal injection of 10 μg Id, Id-CTLA4Y104A, or Id-CTLA4 and bled 2 weeks after each immunization. First immunization, ▪; 2nd immunization, ■. Anti-Id titers in immune sera were determined by ELISA, as described in “Materials and methods.” The data are presented as the mean ± SD for 5 animals in each group.

Reduction of anti-Id Ab response by immunization with Id-CTLA4Y104A mutant protein.

Mice were immunized twice by intraperitoneal injection of 10 μg Id, Id-CTLA4Y104A, or Id-CTLA4 and bled 2 weeks after each immunization. First immunization, ▪; 2nd immunization, ■. Anti-Id titers in immune sera were determined by ELISA, as described in “Materials and methods.” The data are presented as the mean ± SD for 5 animals in each group.

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