The concentration of PAI-1 levels in patients with meningococcemia.

PAI-1 levels were measured by immunologic assay at the time of diagnosis in patients with meningococcemia who developed multiorgan failure and purpura fulminans (group I) and patients who did not develop multiorgan failure and purpura fulminans (group II). PAI-1 was higher in group I (mean ± SD of 1222.9 ± 1319 ng/mL) than in group II (185 ± 296 ng/mL), *P = .02. Statistical analysis was performed using a Mann-Whitney test.