Primary cutaneous anaplastic large cell lymphomas.

(A) Macroscopic appearance: ulcerated reddish-violet tumor of the skin. (B) Histologic appearance of the same lesion as in (A) at low magnification (hematoxylin and eosin). (C) Cytologic composition of the same lesion as in (A) and (B). Note the presence of many large anaplastic cells; they are strongly CD30⁺ (not shown) (hematoxylin and eosin). (D) Immunoreactivity of the same lesion as in (A), (B), and (C) for the cytotoxic molecule granzyme B. All of the tumor cells are strongly positive (antibody clone GrB-7, avidin-biotin-peroxidase).