Fig. 2.
Fig. 2. Schematic of putative MLL-GMPS chimeric oncoproteins. / (A) The 3969-amino acid (aa) MLL protein contains an AT hook DNA-binding motif (aa 170-310), a repression domain (aa 1101-1400), a DNA methyltransferase domain (aa 1153-1219), zinc fingers (aa 1434-1917), and an activation domain (aa 2340-3123).2122(B) The 693-aa GMPS protein contains a GAT domain (aa 1-215) and a synthetase domain (aa 244-250)1014 (GenBank accession no.P49915). (C) Predicted 2090-aa fusion protein resulting fromMLL exon 7-GMPS-fusion transcript. (D) Predicted 2128-aa fusion protein resulting from MLL exon 8-GMPS-fusion transcript. The MLL AT hook motif, repression domain and DNA methyltransferase domain, and the GMPS GAT and synthetase domains are retained in the chimeric oncoproteins; the zinc fingers and activation domain of MLL would not be retained.

Schematic of putative MLL-GMPS chimeric oncoproteins.

(A) The 3969-amino acid (aa) MLL protein contains an AT hook DNA-binding motif (aa 170-310), a repression domain (aa 1101-1400), a DNA methyltransferase domain (aa 1153-1219), zinc fingers (aa 1434-1917), and an activation domain (aa 2340-3123).21,22(B) The 693-aa GMPS protein contains a GAT domain (aa 1-215) and a synthetase domain (aa 244-250)10 14 (GenBank accession no.P49915). (C) Predicted 2090-aa fusion protein resulting fromMLL exon 7-GMPS-fusion transcript. (D) Predicted 2128-aa fusion protein resulting from MLL exon 8-GMPS-fusion transcript. The MLL AT hook motif, repression domain and DNA methyltransferase domain, and the GMPS GAT and synthetase domains are retained in the chimeric oncoproteins; the zinc fingers and activation domain of MLL would not be retained.

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