Graphical representation of Apaf-1 and procaspase levels from paired samples after corrections for loading based on content of histone H1 as described in “Materials and methods.”

Analysis using this same methodology demonstrated increased levels of the apoptotic regulator Mcl-1 in over half of the same paired samples.54 Shaded circles indicate patients who achieved a CR; open circles, patients who did not achieve a CR; solid lines, AML; dotted lines, ALL.