Fig. 3.
Fig. 3. Subnuclear localizations of MLL-ELL and wild-type ELL. / Mouse embryo fibroblasts were transfected with FLAG-tagged MLL (A), wild-type ELL (B), MLL-ELL (C), MLL-ELLΔ150-200 (D), or MLL-ELLΔ374-620 (E). Transfected mouse embryo fibroblasts were stained with a FLAG-specific mAb (A) to detect wild-type MLL or an ELL-specific mAb (B-E) to detect wild-type and chimeric ELL proteins. ELL exhibited a diffuse pattern, whereas ELL fusion proteins were distributed in a punctate and diffuse pattern indistinguishable from that of wild-type MLL.

Subnuclear localizations of MLL-ELL and wild-type ELL.

Mouse embryo fibroblasts were transfected with FLAG-tagged MLL (A), wild-type ELL (B), MLL-ELL (C), MLL-ELLΔ150-200 (D), or MLL-ELLΔ374-620 (E). Transfected mouse embryo fibroblasts were stained with a FLAG-specific mAb (A) to detect wild-type MLL or an ELL-specific mAb (B-E) to detect wild-type and chimeric ELL proteins. ELL exhibited a diffuse pattern, whereas ELL fusion proteins were distributed in a punctate and diffuse pattern indistinguishable from that of wild-type MLL.

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