Fig. 2.
Early increase in the number of circulating GMCs observed before a subsequent progressive decrease in the fraction and absolute number of circulating GMCs.
Kinetics of circulating cells in patient no. 7 (A), patient no. 8 (B), and patient no. 9 (C) with a follow-up of more than 1 year. ◊ indicates the percentage of GMCs among circulating lymphocytes; ○, the absolute number of circulating GMCs; and ▵, lymphocytes. For patient no. 9 (panel C), circulating GMCs after day 220 were still detected, but only by nested PCR (less than 10−5 cells); the latest date analyzed is day 500. The fourth patient, no. 6, with a follow-up of more than 1 year had very low (nonquantifiable) levels of circulating GMCs early after BMT before receiving GCV for acute GVHD (D20).