Fig. 5.
Fig. 5. BCL-6 and BCL-2 expression in reactive lymph node and follicular lymphoma. / (A) Double staining for BCL-6 and BCL-2 in reactive lymph node showing analogy between BCL-6 and BCL-2 expression in thymic cortex (Figure4A,B) and germinal centers of lymphoid follicles. BCL-6+cells (nuclear, brown) are present in germinal centers, while BCL-2+ cells (cytoplasmic, blue) are seen primarily outside germinal centers. (B) Higher magnification shows that most germinal center cells express BCL-6 and are BCL-2−. Only scattered cells in germinal centers are BCL-2+ and do not express BCL-6. (C) Double staining for BCL-6 and BCL-2 in a case of follicular lymphoma showing analogy between the pattern of BCL-6 (nuclear, brown) and BCL-2 (cytoplasmic, blue) coexpression between follicular lymphoma and T-LBL (Figure 4C). Original magnification × 100 (A), × 1000 (B), × 1000 (C).

BCL-6 and BCL-2 expression in reactive lymph node and follicular lymphoma.

(A) Double staining for BCL-6 and BCL-2 in reactive lymph node showing analogy between BCL-6 and BCL-2 expression in thymic cortex (Figure4A,B) and germinal centers of lymphoid follicles. BCL-6+cells (nuclear, brown) are present in germinal centers, while BCL-2+ cells (cytoplasmic, blue) are seen primarily outside germinal centers. (B) Higher magnification shows that most germinal center cells express BCL-6 and are BCL-2−. Only scattered cells in germinal centers are BCL-2+ and do not express BCL-6. (C) Double staining for BCL-6 and BCL-2 in a case of follicular lymphoma showing analogy between the pattern of BCL-6 (nuclear, brown) and BCL-2 (cytoplasmic, blue) coexpression between follicular lymphoma and T-LBL (Figure 4C). Original magnification × 100 (A), × 1000 (B), × 1000 (C).

Close Modal
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal