Role of adhesive interactions and ECM components in the apoptosis of B-CLL cells.

B-CLL cells were cultured for 1 and 3 days either with ECV-304 cells in the presence or absence of 10 μg/mL of the indicated mAbs or with a complex ECM obtained by EC lysis with 0.5% sodium deoxycholate. The results are compared with the percentage of apoptosis observed in the absence (CM) or presence (ECCM) of soluble factors. Data are presented as the mean ± SEM and are representative of at least 3 experiments.