Distinct target cells for p210 ΔSH2-induced CML-like disease and B-lymphoid leukemia.

Genomic DNA from the indicated hematopoietic tissues and lineages (LN, lymph node; PE, pleural effusion; BM; bone marrow; PB, peripheral blood; Mφ, macrophages) from an animal with simultaneous CML-like disease and B-lymphoid leukemia was digested withBglII and hybridized with a radioactive probe from the neomycin resistance gene. Control DNA (Con) from a cell line containing a single BCR/ABL provirus is in the first lane on the left. DNA size markers (in kb) are at left, whereas the positions of 4 unique proviral clones in peripheral blood neutrophils and peritoneal macrophages are indicated by asterisks at the right.