Fig. 6.
Effect of anti-GP Ibα monoclonal antibodies on shear-induced platelet aggregation.
Shear-induced aggregation in platelet-rich plasma was measured in the absence of antibodies or after pre-incubating the sample with 25 μg/mL antibody (a concentration that far exceeds the saturating concentration for each antibody) for 5 minutes at ambient temperature before the application at 90 dynes/cm2 of shear stress in a cone-and-plate viscometer. Results are the means of 4 to 8 experiments performed using different donors. *P < .05; **P < .001.
