Epitopes for anti-vWF monoclonal antibodies.

Structure of the vWF A1 domain based on the radiograph crystal coordinates39 with highlighted sequences representing epitopes for the anti-vWF antibodies 6G1 and CR2.7 The Cα locations of gain-of-function point mutations in type 2B von Willebrand disease are shown as van der Waal spheres.38The figure was generated using the Quanta package (MSI, San Diego, CA).