A synthetic MMPi blocks in vitro MK platelet formation

. (A) In vitro–generated platelets possess forward and log side scatter profile characteristics of in vivo–generated platelets. (B) The addition of a synthetic MMPi to the MK cultures resulted in a 4-fold decrease in the number of in vitro–generated platelets. Results are representative of 3 separate experiments and 4 independent platelet quantifications (n = 4; ***P < .001).