KGF facilitates engraftment postallogeneic BMT.

C57BL/6 recipient mice were sublethally irradiated (6 Gy) (day −1) and given T-cell–depleted BALB/c BM (day 0). Three KGF treatment schedules were compared (5 mg/kg per day, sc). Group 1: control BMT group; group 2: KGF given on days −4, −3, and −2 before BMT; group 3: KGF given on days −4, −3, −2, and 0 to 14 (every day); group 4: KGF given on days −4, −3, −2, and 3 times per week from day 0 through 14. Engraftment of donor cells was evaluated by FACS as described in “Materials and methods.” Results for individual mice are shown for donor cell engraftment in peripheral blood on day 57 (A) and day 105 (B) as well as in bone marrow on day 105 (C). Maintenance of engraftment in peripheral blood for individual KGF-treated mice is shown in panel D.