WBCT of vector-treated hemophilic dogs.

Blood was collected from the dogs at the indicated times prior to and following vector treatment and assessed for WBCT. (A) Dogs treated with Av3H8401 at a dose of 3 × 1012 particles/kg. (B) Dogs treated with Av3H8401 at a dose of 6 × 1011particles/kg. Pretreatment WBCT for dog A was 22 minutes; at 22 months, WBCT was 16 minutes. Pretreatment WBCT for dog B was 16 minutes; at 22 months, WBCT was 20 minutes. Pretreatment WBCT for dog C was 20 minutes; at 16 months, WBCT was 16 minutes 45 seconds. Pretreatment WBCT for dog D was 22 minutes; at 16 months, WBCT was 15 minutes 45 seconds.