Platelet counts and fibrinogen levels of treated dogs.

Blood was collected from the dogs at the indicated times prior to and following vector treatment and platelet and fibrinogen levels were measured. (A) Platelet counts in the dogs treated with the higher vector dose (3 × 1012 particles/kg). (B) Platelet counts in the dogs treated with the lower vector dose (6 × 1011particles/kg). (C) Fibrinogen levels in the dogs treated with the higher vector dose. Pretreatment platelet counts for dog A were 231 (× 1109/L); 22-month counts were 276 (× 1109/L). Pretreatment platelet counts for dog B were 169 (× 1109/L); 22-month counts were 240 (× 1109/L). Pretreatment platelet counts for dog C were 405 (× 1109/L); 16-month counts were 185 (× 1109/L). Pretreatment platelet counts for dog D were 312 (× 1109/L); 16-month counts were 168 (× 1109/L).