Schematic presentation of reported c-mplmutations and predicted alterations in the c-Mpl protein.

The boxes at the left side represent the exons of the coding sequence of c-mpl, mutations found in patients with CAMT are indicated with horizontal bars. The resulting alterations in the c-Mpl protein are shown at the right side. Horizontal gray bars represent the consensus pairs of cysteine residues in cytokine receptors. The signal peptide (SP), the hydrophilic insert in the first cytokine receptor domain (HR), and the transmembrane region (TM) are indicated by gray boxes.