DCI in patients during L1 therapy.

Blood samples from 11 patients with thalassemia major were taken immediately before (0 minute) and at intervals of 30 minutes after administration of L1 (75 mg/kg) per os. Two groups of patients were tested, 8 in Israel (open symbols) and 3 in Thailand (filled symbols). Serum was isolated from the samples after overnight storage at 4°C, and stored frozen. All samples were assayed for DCI in duplicate as described in “Patients, materials, and methods.” Dashed line indicates 0 value.