Effect of paclitaxel and carboplatin on stromal cell elaboration of Tpo and SCF.

Confluent cultures of normal human marrow fibroblasts were exposed to paclitaxel and carboplatin as described in “Patients, materials, and methods” for 6, 24, and 48 hours. Culture supernatants were then harvested and assayed for Tpo (■) and SCF (▪) by ELISA. Results are compared to baseline, which was arbitrarily defined as 100% in the control cultures. Data from 3 independent experiments are pooled together, and plotted as mean ± SD.