FGFR3 activating mutations in TD and MM.

Schematic representation of FGFR3 receptor, with the 3 Ig-like domains (I, II, and III), the transmembrane (TM) domain, and the 2 tyrosine kinase (TK) domains. At the top of the diagram are shown the FGFR3 mutations reported in TD. Shaded are the mutations that we also identified in MM. At the bottom of the diagram are listed the mutations present uniquely in MM. Numbers indicate FGFR3 codons, and asterisks indicate stop codons. Arrowheads and smaller numbers indicate the oligonucleotides used in RT-PCR reactions to screen for mutations. The table summarizes all the FGFR3 mutations we found in MM.