Fig. 5.
Tumorigenicity of K650E expressing NIH 3T3 cells in nude mice
. (A) 105, 5 × 105, and 9 × 105 NIH 3T3 cells transfected with pCEFL (upper left flank), K650E (upper right flank), and wild-type FGFR3 (lower right flank) were subcutaneously injected into 6-week-old nude mice. A representative mouse that received 9 × 105 cells is shown 19 days after the injection. (B) Microscopic appearance of a section of K650E expressing tumor tissue stained with hematoxylin and eosin. An abundance of blood vessels is shown.
