Fig. 4.
Effects of As2O3 on tRA-induced PML-RARα degradation and gene modulation.
(A) PML-RARα and RARα protein levels. Anti-RARα antibody was used to detect PML-RARα and RARα. (B) Northern blot analysis of tRA inducible gene expression. NB4 cells were treated with different concentrations of tRA with or without 0.5 μM As2O3 for 4 days.