Fig. 5.
Fig. 5. Hemophilic mutations with 1-st/2-st discrepancy are located at or close to the A domain interfaces. / Global view of the FVIII A domain model marking the positions ofALA284, ARG531, and ARG282 at the A1-A2 interface; SER289 and TYR1979 at the A1-A3 interface close to the pseudo-threefold axis; andHIS1954, ASN694, MET1947, andARG698 at, or adjacent to, the A2-A3 interface.

Hemophilic mutations with 1-st/2-st discrepancy are located at or close to the A domain interfaces.

Global view of the FVIII A domain model marking the positions ofALA284, ARG531, and ARG282 at the A1-A2 interface; SER289 and TYR1979 at the A1-A3 interface close to the pseudo-threefold axis; andHIS1954, ASN694, MET1947, andARG698 at, or adjacent to, the A2-A3 interface.

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