Alignment of mouse and human Lutheran glycoprotein sequences.

Identical amino acid residues and conservative substitutions (+) between the mouse and human sequences are indicated. Residues are numbered from the known N-terminal residue in human Lu gp. The 2 cysteine residues (*) within each of the 5 predicted IgSF domains are conserved. Potential N-glycosylation sites are boxed—3 of the 4 sites in the mouse sequence are conserved. The proline-rich, putative SH3-binding site within the cytoplasmic domain of human Lu gp is underlined—this motif is partly conserved in the mouse sequence. D1-D5 indicates 5 extracellular, IgSF domains; TM, transmembrane region. The cDNA and translated amino acid sequences have been submitted to GenBank (accession number AF221507).