Sequence of the sH-IgM.22 VH.

The sequence is aligned according to the numbering system of human VH sequences in Kabat et al.26 The sH-IgM 22 VH is a member of VH subgroup III. Underlined amino acids have been confirmed by protein sequencing. Amino acid sequence corresponds to sH-IgM.22 nucleotide sequence. sH-IgM.22 VH type A and type B sequences are represented only with nucleotides that differ from IGHV3-30/3-30-05*01, IGHJ4*02, and IGHD2-21*02 germline sequences.27 Two amino acid replacements in the protein sequence of SH-IgM.22 VH type B are printed in parentheses.