Fig. 1.
In situ hybridization showing expression of IP-10, Mig, and I-TAC mRNA in human thymus.
Consecutive thymic sections were hybridized with35S-labeled IP-10, Mig, or I-TAC antisense or sense probes. Positive signal with the IP-10 (A), Mig (B), and I-TAC (C) antisense probes (dark field, original magnification × 40) is visible mainly in the medullary areas, whereas virtually no signal is visible with the I-TAC sense probe (D) (dark field, original magnification × 40) as well as with the IP-10 or Mig sense probes (data not shown). The IP-10 signal is especially localized in single cells scattered in the medulla (E), whereas the Mig signal predominates at the level of Hassall corpuscles (F) (bright field, original magnification × 400).
