Survival and serial change of body weight (BW) and total WBC of BALB/c mice after BMT.

Survival (Ai,ii), serial change of BW (Bi,ii) and total WBC count (Ci,ii) of BALB/c mice given 10 Gy TBI followed by 2 × 10⁷ BM cells and 10⁷ or 5 × 10⁷ spleen cells from C57BL/6 mice (○), 2 × 10⁷ BM cells and 10⁷ or 5 × 10⁷ spleen cells from C57BL/6 mice and daily oral administration of TAK-603 (50 mg/kg/100 μL 0.5% methylcellulose solution) from the day of transplantation to 45 days after transplantation (●), and 2 × 10⁷ BM cells and 10⁷ or 5 × 10⁷ spleen cells from BALB/c (syngeneic) mice (▴). The BW (B) and total WBC counts (C) of the survivors were measured once every 3 days from the day of transplantation to 45 days after transplantation. The data represent mean ± SD. *P < .05