Effect of TAK-603 on the population of Th1 (CD45RO⁺CD62L⁻) or Th2 (CD45RO⁺CD62L⁺)-like cells in CD4⁺cells from PBMNC and SMNC.

The percentage of Th1-like cell (A) or Th2-like cell (B) population in CD4⁺ cells of PBMNC or SMNC from BALB/c mice given 10 Gy TBI followed by 2 × 10⁷ BM cells and 1 × 10⁷ (Ai,Bi) or 5 × 10⁷ (Aii,Bii) spleen cells from C57BL/6 (GVHD; ▩), 2 × 10⁷ BM cells and 1 × 10⁷ (Ai,Bi) or 5 × 10⁷ (Aii,Bii) spleen cells from C57BL/6 and daily oral administration of TAK-603 (GVHD+TAK; ▨) and 2 × 10⁷ BM cells and 1 × 10⁷ (Ai,Bi) or 5 × 10⁷ (Aii,Bii) spleen cells from BALB/c mice (syngeneic; ░). The data represent mean ± SD of 3 mice in each group. *P < .01; **P < .05.