Fig. 4.
![Fig. 4. Proliferative responses in the. / WHN−/− patient or theWHN+/− healthy donor brother.(A) Proliferative response evaluated through [3H]-thymidine incorporation after stimulation of peripheral blood mononuclear cells by CD3 cross-linking. PBMCs from the WHN−/−patient were analyzed at regular intervals during the 6 years after allogeneic BMT. The results are expressed as cpm. Dotted lines indicate mean ± SD of control values. (B) Comparison 6 years after BMT of the proliferative response to several mitogens between cells grown in the WHN−/− recipient and in theWHN+/− donor environment. Exogenous rIL-2 was used at a concentration of 100 U/mL.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/97/4/10.1182_blood.v97.4.880/5/h80410717004.jpeg?Expires=1735586927&Signature=rQnvBd5INNp7tchbAL7bLpGxqYIczBHqf8JTmgcUIoTC1McrgaUo-NRdSGjjFmWwJZjL5Zpi9J7LJG6VXRVK-1qPXwN1lIM16JMOWNs47uWl6JfRXrWUorl1wqenp7qhDa2jDDxI8Kl5IcxkmzWYwieTDiBy5ndwBMtSBxRv3m-1bVekDgK8O0QCY7Uac5ClCRnW3f-oxid1-viJ9ELF2MY2C-z~2Mfx0lUwPIyJuxaawTuZldQrEUNwhDeOUXrNT47ImLYWYlpxkKfw5ijkwALTmYU1f5HrmANCLw8z5s0fHH3URgHitOaTQgftwz0MIfGi2lLD4YW6dBUXopiNhA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Proliferative responses in the
WHN−/− patient or theWHN+/− healthy donor brother.(A) Proliferative response evaluated through [3H]-thymidine incorporation after stimulation of peripheral blood mononuclear cells by CD3 cross-linking. PBMCs from the WHN−/−patient were analyzed at regular intervals during the 6 years after allogeneic BMT. The results are expressed as cpm. Dotted lines indicate mean ± SD of control values. (B) Comparison 6 years after BMT of the proliferative response to several mitogens between cells grown in the WHN−/− recipient and in theWHN+/− donor environment. Exogenous rIL-2 was used at a concentration of 100 U/mL.
