Recognition of wild-type Tax 11-19 peptide and altered Tax 11-19 (G4R) peptide by Tax 11-19–specific CTL clone restricted with HLA-A*02.

Target Hmy-A2 cells were prepulsed with 1 μM of each peptide. After washing out the excess unbound peptides, Tax 11-19–specific CTL cells (N1216) were added. The specific lysis is represented by mean ± SD. Tax (♦), wild-type Tax peptide 11-19 (LLFGYPVYV). G4R (▪), altered Tax peptide at position 4 from glycine to arginine (LLFRYPVYV). M1 (▴), control influenza virus peptide (GILGFVFTL) known to bind HLA-A2.