Effect of ablation of TH2 cytokines on resistance toC albicans in mice with T-cell–depleted allogeneic BMT.

Recipient C3H/HeJ mice were irradiated and reconstituted with T-cell–depleted BM from IL-4– or IL-12p40–deficient (IL-4 KO and IL-12 KO, respectively) as well as (A) wild-type (WT) mice or as in Figure 1 legend. Two weeks later, mice were intravenously infected with low-virulent PCA-2 C albicans and reinfected with 10⁶ virulent CA-6 C albicans cells 2 weeks after the primary infection. Treatments with sIL-4R or anti–IL-10R mAb were done at the time of (B) BMT or (C) primary infection. MST indicates median survival time in days; CFUs, a week after reinfection; none, vehicle alone. *Indicates P < .05 (BMT mice vs donor mice).