Effects of in vivo depletion of T cells on survival following vaccination with Id-encoding adenoviruses.

Groups of 15 mice were vaccinated with Ad-IdhuCR or Ad-CTRLhuCR, then challenged 3 weeks later (day 0) with 1000 38C13 tumor cells SQ and followed for survival. On days −6, −5, −4, and 0 and weekly thereafter, mice receiving Ad-IdhuCR were treated with CD4⁺ and CD8⁺ T-cell depleting mAbs GK1.5 and HB129 or isotype control mAbs. Animals vaccinated with Ad-CTRLhuCR also received control mAbs. ▵ indicates Ad-IdhuCR plus anti-CD4/CD8; ▴ indicates Ad-IdhuCR plus control mAbs; ⋄ indicates Ad-CTRLhuCR plus control mAbs.