Fig. 5.
Fig. 5. GM-CSF is not required for induction of CML-like disease by. / BCR/ABL. Kaplan–Meier-style survival curve for recipients of marrow transduced with p210 BCR/ABL. The genotypes of donor and recipient are indicated by the dashed lines; all mice were of Balb/c background. The number of recipients in each arm is shown in parentheses. The prolonged survival ofGm-csf−/− recipients ofGm-csf-−/− BCR/ABL-transduced marrow relative to the wild-type recipients of wild-type transduced marrow was significant (P = .002, Mantel-Cox test), whereas there was no significant difference in survival between any of the other transplant arms (P = .1). SeveralGm-csf −/− recipients transplanted withBCR/ABL-transduced wild-type marrow failed to engraft and died before day 12 (see text) and were not included on the curve.

GM-CSF is not required for induction of CML-like disease by

BCR/ABL. Kaplan–Meier-style survival curve for recipients of marrow transduced with p210 BCR/ABL. The genotypes of donor and recipient are indicated by the dashed lines; all mice were of Balb/c background. The number of recipients in each arm is shown in parentheses. The prolonged survival ofGm-csf−/− recipients ofGm-csf-−/−BCR/ABL-transduced marrow relative to the wild-type recipients of wild-type transduced marrow was significant (P = .002, Mantel-Cox test), whereas there was no significant difference in survival between any of the other transplant arms (P = .1). SeveralGm-csf−/− recipients transplanted withBCR/ABL-transduced wild-type marrow failed to engraft and died before day 12 (see text) and were not included on the curve.

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