Lack of redundancy between IL-3 and GM-CSF in pathogenesis of

BCR/ABL-induced CML-like leukemia.Kaplan-Meier–style survival curve for recipients of marrow transduced with p210 BCR/ABL. The genotypes of donor and recipient are indicated by the dashed lines; all mice were of Balb/c background. The number of recipients in each arm is shown in parentheses. Several double-knockout mice transplanted with BCR/ABL-transduced double-knockout marrow failed to engraft at a lower cell dose (see text) and were not included on the curve. The survival of double-knockout recipients of double-knockout–transduced marrow was significantly shorter than that of the wild-type mice (P = .005, Mantel-Cox test).